Understanding Disease at the Organelle Level



Doctors said Kirstie Tancock may not make it to the altar without a new set of lungs. 

The 21-year-old from Devon in the United Kingdom has known since birth that she was living on borrowed time -- she was born with cystic fibrosis (CF). And just days before her dream wedding last year, her lungs filled with a life-threatening infection. 
"I have spent every moment living like it was my last," said Kirstie, who, until her health spiraled downward, was a fit athlete . 
Kirstie has known since a young age that her life was expected to be short. She was born with CF, an inherited chronic disease that affects the lungs and digestive system. 
About 1,000 new cases are diagnosed each year in the U.S., and about one in three people with the disease will die waiting for a lung transplant.

What roles do organelles play in diseases such as cystic fibrosis? So far, we have learned about the normal structure and function of cell organelles. But, sometimes organelles may function abnormally leading to disease. In this WebQuest, you and your lab partner will explore the important connections between organelles and disease.

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